Search results for "Beta-3 adrenergic receptor"

showing 3 items of 3 documents

Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell pro…

2013

Abstract The beta3 adrenergic receptor (B3-AR) reportedly induces cell proliferation, but the signaling pathways that were proposed, involving either Gs or Gi coupling, remain controversial. To further investigate the role of G protein coupling in B3-AR induced proliferation, we stimulated primary human myometrial smooth muscle cells with SAR150640 (B3-AR agonist) in the absence or presence of variable G-protein inhibitors. Specific B3-AR stimulation led to an Erk1/2 induced proliferation. We observed that the proliferative effects of B3-AR require two Erk1/2 activation peaks (the first after 3 min, the second at 8 h). Erk1/2 activation at 3 min was mimicked by forskolin (adenylyl-cyclase a…

Beta-3 adrenergic receptorGs alpha subunitMAP Kinase Signaling SystemMyocytes Smooth MuscleProliferationG protein coupled receptorBiologyGTP-Binding Protein alpha Subunits Gi-GoPertussis toxinchemistry.chemical_compoundErk1/2Protein kinasesCyclinsReceptors Adrenergic betaGTP-Binding Protein alpha Subunits GsHumansMolecular BiologyPI3K/AKT/mTOR pathwayCells CulturedG protein-coupled receptorCell ProliferationForskolinColforsinBeta-3 adrenergic receptorCell BiologyCell biologychemistryGene Expression RegulationPertussis ToxinMyometriumFemaleSignal transductionProto-oncogene tyrosine-protein kinase SrcBiochimica et Biophysica Acta (BBA) - Molecular Cell Research
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Editorial on “Beta-3 adrenergic receptor is expressed in acetylcholine-containing nerve fibers of the human urinary bladder: An immunohistochemical s…

2017

Beta-3 adrenergic receptormedicine.medical_specialtyUrinary bladderbusiness.industryUrologyUrinary Bladder02 engineering and technologyAcetylcholineNerve Fibers020210 optoelectronics & photonicsmedicine.anatomical_structureEndocrinologyCholinergic FibersReceptors Adrenergic beta-3Internal medicine0202 electrical engineering electronic engineering information engineeringmedicineHumansImmunohistochemistryNeurology (clinical)businessAcetylcholinemedicine.drugNeurourology and Urodynamics
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Evidence for transforming growth factor-beta 3 gene polymorphism in non-syndromic cleft lip and palate patients from indian sub-continent

2011

Objectives: Orofacial clefts are major human birth defects with complex etiology. Previous studies have proposed Transforming growth factor - beta 3 (TGF-β3) gene as a key player in contributing to non-syndromic cleft lip and palate, however none of the studies have yet included Indian population. Hence this study was designed to detect TGF-β3 gene polymorphism in nonsyndromic cleft lip and palate patients from Indian population which is genetically distinct from previously studied populations. Study Design: Peripheral blood samples of forty non-syndromic cleft lip and palate patients and forty unaffected individuals were collected for a case – control study design. Ethical clearance from t…

Beta-3 adrenergic receptorCleft LipDentistryIndiaBioinformaticslaw.inventionTransforming Growth Factor beta3lawMedicineHumansGeneral DentistryGenePolymerase chain reactionOral Medicine and PathologyPolymorphism Geneticbusiness.industryInstitutional review board:CIENCIAS MÉDICAS [UNESCO]Cleft PalateOtorhinolaryngologyTransforming growth factor beta 3UNESCO::CIENCIAS MÉDICASEtiologySurgeryResearch-ArticleGene polymorphismbusinessNon syndromic
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